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Jürgen Scheller Selected Research

Cytokine Receptor gp130

1/2022A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2.
1/2018The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.
1/2013IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.
6/2011Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model.
7/2007Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo.
1/2005No inhibition of IL-27 signaling by soluble gp130.

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Jürgen Scheller Research Topics

Disease

26Inflammation (Inflammations)
01/2021 - 08/2006
20Neoplasms (Cancer)
12/2021 - 08/2006
12Autoimmune Diseases (Autoimmune Disease)
12/2021 - 05/2007
12Rheumatoid Arthritis
12/2021 - 01/2005
10Infections
01/2022 - 01/2005
8Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
12/2021 - 08/2006
7Colonic Neoplasms (Colon Cancer)
02/2014 - 01/2005
6Crohn Disease (Crohn's Disease)
12/2021 - 01/2005
5Myocardial Infarction
01/2017 - 10/2010
5Colitis
09/2014 - 08/2007
5Peritonitis
02/2014 - 01/2005
4Ischemia
11/2018 - 09/2014
3Arthritis (Polyarthritis)
01/2019 - 01/2009
3Infarction (Infarctions)
11/2018 - 01/2014
3Asthma (Bronchial Asthma)
02/2016 - 08/2006
3Kaposi Sarcoma (Kaposi's Sarcoma)
06/2011 - 09/2006
2Tuberculosis (Tuberculoses)
01/2017 - 10/2012
2Carcinogenesis
02/2016 - 02/2009
2Sepsis (Septicemia)
11/2015 - 06/2011
2Reperfusion Injury
10/2015 - 09/2014
2Hypertension (High Blood Pressure)
12/2014 - 07/2007
2Psoriasis (Pustulosis Palmaris et Plantaris)
12/2014 - 01/2011
2Neurodegenerative Diseases (Neurodegenerative Disease)
06/2014 - 02/2014
2Atherosclerosis
02/2014 - 07/2012
2Liver Cell Adenoma (Hepatocellular Adenoma)
04/2012 - 08/2010
2Hepatocellular Carcinoma (Hepatoma)
09/2006 - 09/2006
1Virus Diseases (Viral Diseases)
01/2022
1COVID-19
01/2022
1Cytokine Release Syndrome
01/2022
1Ulcerative Colitis
12/2021
1Hemorrhage
01/2021
1Thrombocytopenia (Thrombopenia)
01/2021
1Liver Diseases (Liver Disease)
01/2021
1Liver Cirrhosis (Hepatic Cirrhosis)
10/2019
1Pneumonia (Pneumonitis)
01/2017
1Ventricular Remodeling
10/2016
1Carcinoma (Carcinomatosis)
02/2016
1Sleep Deprivation
11/2015
1Lupus Nephritis
07/2015
1Nephritis
07/2015
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
12/2014
1Skin Diseases (Skin Disease)
12/2014
1Cicatrix (Scar)
09/2014
1Coronary Disease (Coronary Heart Disease)
09/2014
1Myocardial Ischemia (Ischemic Heart Diseases)
09/2014
1Body Weight (Weight, Body)
06/2014
1Large Granular Lymphocytic Leukemia
04/2014
1Abscess
03/2014
1Pancreatitis
02/2014
1Pancreatic Neoplasms (Pancreatic Cancer)
02/2014
1Ovarian Neoplasms (Ovarian Cancer)
02/2014

Drug/Important Bio-Agent (IBA)

46Interleukin-6 (Interleukin 6)IBA
01/2022 - 05/2005
27CytokinesIBA
12/2021 - 01/2005
10Proteins (Proteins, Gene)FDA Link
01/2022 - 09/2006
10Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
01/2022 - 09/2006
6Cytokine Receptor gp130IBA
01/2022 - 01/2005
6InterleukinsIBA
12/2021 - 09/2006
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2014 - 06/2009
3olamkiceptIBA
12/2021 - 06/2011
3Interleukin-11 (Interleukin 11)IBA
12/2021 - 04/2012
3ChemokinesIBA
01/2021 - 09/2010
3Interleukin-23 (Interleukin 23)IBA
11/2018 - 10/2015
3STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
01/2014 - 09/2006
2Monoclonal AntibodiesIBA
01/2022 - 09/2014
2G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2021 - 12/2009
2Hyaluronic Acid (Hyaluronan)IBA
11/2018 - 01/2014
2Metalloproteases (Metalloproteinases)IBA
11/2016 - 08/2010
2Dextrans (Dextran)FDA Link
09/2014 - 02/2010
2sodium sulfate (sodium bisulfate)FDA LinkGeneric
09/2014 - 02/2010
2CollagenIBA
09/2014 - 10/2010
2Phosphotransferases (Kinase)IBA
04/2014 - 07/2013
2LigandsIBA
04/2012 - 08/2010
2Interleukin-27 (Interleukin 27)IBA
12/2007 - 01/2005
1Bispecific AntibodiesIBA
01/2022
1Bile Acids and Salts (Bile Acids)IBA
01/2021
1Sirtuin 3IBA
01/2020
1SirtuinsIBA
01/2020
1NAD (NADH)IBA
01/2020
1Etanercept (Enbrel)FDA Link
10/2019
1TenascinIBA
01/2017
1AerosolsIBA
01/2017
1Adenosine (Adenocard)FDA LinkGeneric
01/2017
1EnzymesIBA
01/2017
1ConnectinIBA
10/2016
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
11/2015
1Acute-Phase Proteins (Acute-Phase Protein)IBA
10/2015
1Reactive Oxygen Species (Oxygen Radicals)IBA
12/2014
1Peroxidase (Myeloperoxidase)IBA
12/2014
1Interleukin-17 (Interleukin 17)IBA
12/2014
1Interleukin-1 (Interleukin 1)IBA
09/2014
1phospholipase D1IBA
09/2014
1C-Reactive ProteinIBA
09/2014
1Transforming Growth Factors (Transforming Growth Factor)IBA
09/2014
1Ciliary Neurotrophic Factor (CNTF)IBA
06/2014
1Nerve Growth Factors (Neurotrophins)IBA
06/2014
1src-Family KinasesIBA
04/2014
1Pharmaceutical PreparationsIBA
02/2014
1CarbohydratesIBA
01/2014

Therapy/Procedure

9Therapeutics
01/2022 - 05/2007
3Ligation
10/2019 - 06/2011